June 18, 2024
Health & Fitness

10 Medications You Should Never Mix With Coffee


Coffee is one of the most widely consumed beverages globally, known for its stimulating effects and rich flavor. However, while coffee can be enjoyed in moderation as part of a balanced diet, it’s essential to be aware of potential interactions between coffee and certain medications. In this article, we’ll explore 10 medications that should never be mixed with coffee, as well as the reasons behind these interactions.

1. Antibiotics

Coffee and other caffeinated beverages can interact with some antibiotics, like ciprofloxacin and levofloxacin, to decrease the absorption and effectiveness of the medication. Compounds in coffee have the ability to bind to antibiotics in the stomach, blocking their correct absorption into the bloodstream. It is best to avoid drinking coffee for a few hours after taking antibiotics in order to ensure maximum efficacy.

2. Thyroid Medications

Thyroid medications, such as levothyroxine, are commonly prescribed to treat thyroid disorders. However, coffee can interfere with the absorption of these medications, leading to reduced effectiveness. Caffeine can impair the absorption of levothyroxine in the gastrointestinal tract, potentially resulting in suboptimal thyroid hormone levels. To avoid this interaction, it’s recommended to take thyroid medications on an empty stomach and wait at least 30 minutes before consuming coffee or other caffeinated beverages.


Coffee and other caffeinated beverages can interact with some antidepressant medications, including tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs), increasing the risk of negative side effects. Caffeine, which is found in coffee, stimulates the central nervous system and can intensify the negative effects of antidepressants, including jitters, anxiety, and sleeplessness. While taking antidepressant medications, it’s best to limit caffeine intake and keep an eye out for any negative reactions to minimize these effects.

4.Blood Pressure Medications

Coffee and other caffeinated beverages may interact with blood pressure medications, such as beta-blockers and calcium channel blockers, and affect blood pressure control. Temporary increases in blood pressure and heart rate brought on by caffeine may negate the effects of these drugs. Coffee drinkers who are on blood pressure medication should exercise caution and keep a close eye on their blood pressure levels for any changes or fluctuations.

5.Anti-Anxiety Medications

Anti-anxiety medications, such as benzodiazepines and certain antipsychotics, can interact with coffee and caffeine, intensifying central nervous system effects. Coffee can potentiate the sedative and calming effects of these medications, leading to increased drowsiness, confusion, and impairment of cognitive function. To avoid excessive sedation and potential adverse effects, it’s recommended to limit caffeine intake while taking anti-anxiety medications and to consult with a healthcare professional if concerns arise.

6. Acid Reflux Medications

Coffee may interact with certain medications, such as proton pump inhibitors (PPIs) and H2 blockers, which are used to treat acid reflux and gastroesophageal reflux disease (GERD), making symptoms worse. Because coffee is acidic, it can increase the production of gastric acid, which may exacerbate reflux symptoms in those who are vulnerable. Limit your coffee consumption and, if needed, choose low-acid varieties to lessen discomfort and the chance of acid reflux flare-ups.

7. Iron Supplements

In order to treat iron deficiency anemia, doctors frequently prescribe iron supplements; however, these supplements may interfere with coffee’s ability to absorb iron. Polyphenols, which are found in coffee, have the ability to bind to dietary iron and prevent the gastrointestinal tract from absorbing it. Iron supplements should ideally be taken empty-handed or with foods high in vitamin C to optimize iron absorption. It’s also best to avoid drinking coffee or tea for a few hours after taking iron supplements.

8. Asthma Medications

Coffee and other caffeinated beverages may interact with some asthma medications, including beta-agonists and theophylline, potentially aggravating asthma symptoms. Due to its bronchodilator properties, caffeine can intensify the effects of certain drugs, causing jitters, palpitations, and an elevated heart rate. When consuming coffee, people with asthma should exercise caution and keep an eye out for any negative reactions or respiratory symptoms.

9. Anticoagulants

Anticoagulant drugs, like heparin and warfarin, are used to stop blood clots and lower the risk of heart attacks and strokes. Coffee, however, has the potential to interfere with anticoagulants and impact platelet function and blood clotting. Due to its mild anticoagulant qualities, caffeine may intensify the effects of certain medications, raising the possibility of bruising or bleeding. People who take anticoagulants should watch how much caffeine they consume and see a doctor if they have any concerns.

10. Oral Contraceptives

Oral contraceptives, commonly known as birth control pills, may interact with coffee and other caffeinated beverages, affecting hormone metabolism and clearance. Coffee contains compounds that can induce liver enzymes responsible for metabolizing hormones, potentially reducing the effectiveness of oral contraceptives. To ensure optimal contraceptive efficacy, it’s advisable to limit caffeine intake while taking oral contraceptives and to use alternative forms of contraception if necessary.


While coffee can be a delightful and energizing beverage, it’s essential to be mindful of potential interactions with certain medications. By understanding the potential risks and taking appropriate precautions, you can enjoy coffee responsibly while minimizing the risk of adverse effects. If you have any concerns or questions about coffee and medication interactions, don’t hesitate to consult with a healthcare professional for personalized advice and guidance. Remember to prioritize your health and well-being by making informed choices and maintaining open communication with your healthcare provider.